A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B
A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B
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Author / Creator
Bosc, D. , Vezenkov, L. , Bortnik, S. , An, J. , Xu, J. , Choutka, C. , Hannigan, A. M. , Kovacic, S. , Loo, S. , Clark, P. G. K. , Chen, G. , Guay-Ross, R. N. , Yang, K. , Dragowska, W. H. , Zhang, F. , Go, N. E. , Leung, A. , Honson, N. S. , Pfeifer, T. A. , Gleave, M. , Bally, M. , Jones, S. J. , Gorski, S. M. and Young, R. N.
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The cysteine protease ATG4B is a key component of the autophagy machinery, acting to proteolytically prime and recycle its substrate MAP1LC3B. The roles of ATG4B in cancer and other diseases appear to be context dependent but are still not well understood. To help further explore ATG4B functions and potential therapeutic applications, we employed a...
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Full title
A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B
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TN_cdi_doaj_primary_oai_doaj_org_article_9a9e47719cda4bf8a6d913a40f60c964
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9a9e47719cda4bf8a6d913a40f60c964
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-29900-x
