Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic sta...
Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell
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Publisher
England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
Mitochondrial dysfunction is associated with activation of the integrated stress response (ISR) but the underlying triggers remain unclear. We systematically combined acute mitochondrial inhibitors with genetic tools for compartment-specific NADH oxidation to trace mechanisms linking different forms of mitochondrial dysfunction to the ISR in prolif...
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Full title
Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell
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TN_cdi_doaj_primary_oai_doaj_org_article_9bc45f9d6d074c74813abb44b0899f54
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9bc45f9d6d074c74813abb44b0899f54
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.49178
