Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple s...
Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Multiple Sclerosis (MS) is characterized by focal CNS inflammation leading to the death of oligodendrocytes (OLs) with subsequent demyelination, neuronal degeneration, and severe functional deficits. Inhibitory chondroitin sulfate proteoglycans (CSPGs) are increased in the extracellular matrix in the vicinity of MS lesions and are thought to play a...
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Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis
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TN_cdi_doaj_primary_oai_doaj_org_article_9c16454ee374473489e0265861603c15
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9c16454ee374473489e0265861603c15
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06505-6