Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insigh...
Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Multidrug resistance (MDR) poses a major challenge to medicine. A principle cause of MDR is through active efflux by MDR transporters situated in the bacterial membrane. Here we present the crystal structure of the major facilitator superfamily (MFS) drug/H
+
antiporter MdfA from
Escherichia coli
in an outward open conformation. Compari...
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Full title
Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism
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TN_cdi_doaj_primary_oai_doaj_org_article_9c31b685bee4442382a7b84e7402aa22
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9c31b685bee4442382a7b84e7402aa22
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06306-x
