CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistan...
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
About this item
Full title
Author / Creator
Vennin, Claire , Mélénec, Pauline , Rouet, Romain , Nobis, Max , Cazet, Aurélie S. , Murphy, Kendelle J. , Herrmann, David , Reed, Daniel A. , Lucas, Morghan C. , Warren, Sean C. , Elgundi, Zehra , Pinese, Mark , Kalna, Gabriella , Roden, Daniel , Samuel, Monisha , Zaratzian, Anaiis , Grey, Shane T. , Da Silva, Andrew , Leung, Wilfred , Mathivanan, Suresh , Wang, Yingxiao , Braithwaite, Anthony W. , Christ, Daniel , Benda, Ales , Parkin, Ashleigh , Phillips, Phoebe A. , Whitelock, John M. , Gill, Anthony J. , Sansom, Owen J. , Croucher, David R. , Parker, Benjamin L. , Pajic, Marina , Morton, Jennifer P. , Cox, Thomas R. , Timpson, Paul and Australian Pancreatic Genome Initiative (APGI)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic cancer tissues and can both promote and restrain disease progression. Here, we interrogate how cancer cells harboring distinct alterations in p53 manipulate CAFs. We reveal the existence of a p53-driven hierarchy, where cancer cells with a gain-of-function (GOF...
Alternative Titles
Full title
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
Authors, Artists and Contributors
Author / Creator
Mélénec, Pauline
Rouet, Romain
Nobis, Max
Cazet, Aurélie S.
Murphy, Kendelle J.
Herrmann, David
Reed, Daniel A.
Lucas, Morghan C.
Warren, Sean C.
Elgundi, Zehra
Pinese, Mark
Kalna, Gabriella
Roden, Daniel
Samuel, Monisha
Zaratzian, Anaiis
Grey, Shane T.
Da Silva, Andrew
Leung, Wilfred
Mathivanan, Suresh
Wang, Yingxiao
Braithwaite, Anthony W.
Christ, Daniel
Benda, Ales
Parkin, Ashleigh
Phillips, Phoebe A.
Whitelock, John M.
Gill, Anthony J.
Sansom, Owen J.
Croucher, David R.
Parker, Benjamin L.
Pajic, Marina
Morton, Jennifer P.
Cox, Thomas R.
Timpson, Paul
Australian Pancreatic Genome Initiative (APGI)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_9cbe7f002204495db0cd437d4360e24c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9cbe7f002204495db0cd437d4360e24c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10968-6
