Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line a...
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The widely used antimalarial combination therapy dihydroartemisinin + piperaquine (DHA + PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid increase in the prevalence of novel mutations in the
Plasmodium falciparum
chloroquine resistance transporter PfCRT following DHA + PPQ implementation. These mutations o...
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Full title
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
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TN_cdi_doaj_primary_oai_doaj_org_article_9e15ba8777674417b0e16955209c6ccc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9e15ba8777674417b0e16955209c6ccc
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05652-0
