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Fidock, David A
Journal title:American Men & Women of Science : A Biographical Directory of Today’s Leaders in Physical, Biological and Related Sciences: DUR-GAK, 2022, p.3494-3494
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Fidock, David A
Journal title:American Men & Women of Science : A Biographical Directory of Today’s Leaders in Physical, Biological and Related Sciences: DUR-GAK, 2021, p.3476-3476
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ArticlesPeer ReviewedFull Text
Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda
Author / Creator:Uwimana, Aline ; Legrand, Eric ; Stokes, Barbara H. ; Ndikumana, Jean-Louis Mangala ; Warsame, Marian ; Umulisa, Noella ; Ngamije, Daniel ; Munyaneza, Tharcisse ; Mazarati, Jean-Baptiste ; Munguti, Kaendi ; Campagne, Pascal ; Criscuolo, Alexis ; Ariey, Frédéric ; Murindahabi, Monique ; Ringwald, Pascal ; Fidock, David A. ; Mbituyumuremyi, Aimable ; Menard, Didier
Publisher:New York: Nature Publishing Group US
Journal title:Nature Medicine, 2020-10, Vol.26 (10), p.1602-1608
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Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
Author / Creator:Eastman, Richard T. ; Fidock, David A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Microbiology, 2009-12, Vol.7 (12), p.864-874
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Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance
Author / Creator:Dogovski, Con ; Xie, Stanley C ; Burgio, Gaetan ; Bridgford, Jess ; Mok, Sachel ; McCaw, James M ; Chotivanich, Kesinee ; Kenny, Shannon ; Gnädig, Nina ; Straimer, Judith ; Bozdech, Zbynek ; Fidock, David A ; Simpson, Julie A ; Dondorp, Arjen M ; Foote, Simon ; Klonis, Nectarios ; Tilley, Leann
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2015-04, Vol.13 (4), p.e1002132
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Accelerated evolution and spread of multidrug-resistant Plasmodium falciparum takes down the latest first-line antimalarial drug in southeast Asia
Author / Creator:Ménard, Didier ; Fidock, David A
Publisher:United States: Elsevier Ltd
Journal title:The Lancet infectious diseases, 2019-09, Vol.19 (9), p.916-917
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Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
Author / Creator:Ross, Leila S. ; Dhingra, Satish K. ; Mok, Sachel ; Yeo, Tomas ; Wicht, Kathryn J. ; Kümpornsin, Krittikorn ; Takala-Harrison, Shannon ; Witkowski, Benoit ; Fairhurst, Rick M. ; Ariey, Frederic ; Menard, Didier ; Fidock, David A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-08, Vol.9 (1), p.3314-13, Article 3314
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Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
Author / Creator:Veiga, M. Isabel ; Dhingra, Satish K. ; Henrich, Philipp P. ; Straimer, Judith ; Gnädig, Nina ; Uhlemann, Anne-Catrin ; Martin, Rowena E. ; Lehane, Adele M. ; Fidock, David A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-05, Vol.7 (1), p.11553-12, Article 11553
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Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival
Author / Creator:Mok, Sachel ; Stokes, Barbara H. ; Gnädig, Nina F. ; Ross, Leila S. ; Yeo, Tomas ; Amaratunga, Chanaki ; Allman, Erik ; Solyakov, Lev ; Bottrill, Andrew R. ; Tripathi, Jaishree ; Fairhurst, Rick M. ; Llinás, Manuel ; Bozdech, Zbynek ; Tobin, Andrew B. ; Fidock, David A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-01, Vol.12 (1), p.530-530, Article 530
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Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance
Author / Creator:Small-Saunders, Jennifer L ; Hagenah, Laura M ; Wicht, Kathryn J ; Dhingra, Satish K ; Deni, Ioanna ; Kim, Jonathan ; Vendome, Jeremie ; Gil-Iturbe, Eva ; Roepe, Paul D ; Mehta, Monica ; Mancia, Filippo ; Quick, Matthias ; Eppstein, Margaret J ; Fidock, David A
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2022-02, Vol.18 (2), p.e1010278-e1010278
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Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance
Author / Creator:Mathieu, Luana C ; Cox, Horace ; Early, Angela M ; Mok, Sachel ; Lazrek, Yassamine ; Paquet, Jeanne-Celeste ; Ade, Maria-Paz ; Lucchi, Naomi W ; Grant, Quacy ; Udhayakumar, Venkatachalam ; Alexandre, Jean Sf ; Demar, Magalie ; Ringwald, Pascal ; Neafsey, Daniel E ; Fidock, David A ; Musset, Lise
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2020-05, Vol.9
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ArticlesPeer ReviewedFull Text
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials
Author / Creator:Antonova-Koch, Yevgeniya ; Meister, Stephan ; Abraham, Matthew ; Luth, Madeline R ; Ottilie, Sabine ; Lukens, Amanda K ; Sakata-Kato, Tomoyo ; Vanaerschot, Manu ; Owen, Edward ; Jado Rodriguez, Juan Carlos ; Maher, Steven P ; Calla, Jaeson ; Plouffe, David ; Zhong, Yang ; Chen, Kaisheng ; Chaumeau, Victor ; Conway, Amy J ; McNamara, Case W ; Ibanez, Maureen ; Gagaring, Kerstin ; Serrano, Fernando Neria ; Eribez, Korina ; Taggard, Cullin McLean ; Cheung, Andrea L ; Lincoln, Christie ; Ambachew, Biniam ; Rouillier, Melanie ; Siegel, Dionicio ; Nosten, François ; Kyle, Dennis E ; Gamo, Francisco-Javier ; Zhou, Yingyao ; Llinás, Manuel ; Fidock, David A ; Wirth, Dyann F ; Burrows, Jeremy ; Campo, Brice ; Winzeler, Elizabeth A
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2018-12, Vol.362 (6419)
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Spiroindolones, a Potent Compound Class for the Treatment of Malaria
Author / Creator:Rottmann, Matthias ; McNamara, Case ; Yeung, Bryan K.S ; Lee, Marcus C.S ; Zou, Bin ; Russell, Bruce ; Seitz, Patrick ; Plouffe, David M ; Dharia, Neekesh V ; Tan, Jocelyn ; Cohen, Steven B ; Spencer, Kathryn R ; González-Páez, Gonzalo E ; Lakshminarayana, Suresh B ; Goh, Anne ; Suwanarusk, Rossarin ; Jegla, Timothy ; Schmitt, Esther K ; Beck, Hans-Peter ; Brun, Reto ; Nosten, Francois ; Renia, Laurent ; Dartois, Veronique ; Keller, Thomas H ; Fidock, David A ; Winzeler, Elizabeth A ; Diagana, Thierry T
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2010-09, Vol.329 (5996), p.1175-1180
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ArticlesPeer ReviewedFull Text
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages
Author / Creator:Bunnik, Evelien M. ; Cook, Kate B. ; Varoquaux, Nelle ; Batugedara, Gayani ; Prudhomme, Jacques ; Cort, Anthony ; Shi, Lirong ; Andolina, Chiara ; Ross, Leila S. ; Brady, Declan ; Fidock, David A. ; Nosten, Francois ; Tewari, Rita ; Sinnis, Photini ; Ay, Ferhat ; Vert, Jean-Philippe ; Noble, William Stafford ; Le Roch, Karine G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-05, Vol.9 (1), p.1910-15, Article 1910
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ArticlesPeer ReviewedFull Text
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
Author / Creator:Sonoiki, Ebere ; Ng, Caroline L. ; Lee, Marcus C. S. ; Guo, Denghui ; Zhang, Yong-Kang ; Zhou, Yasheen ; Alley, M. R. K. ; Ahyong, Vida ; Sanz, Laura M. ; Lafuente-Monasterio, Maria Jose ; Dong, Chen ; Schupp, Patrick G. ; Gut, Jiri ; Legac, Jenny ; Cooper, Roland A. ; Gamo, Francisco-Javier ; DeRisi, Joseph ; Freund, Yvonne R. ; Fidock, David A. ; Rosenthal, Philip J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-03, Vol.8 (1), p.14574-14574, Article 14574
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ArticlesPeer ReviewedFull Text
Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents
Author / Creator:Stokes, Barbara H ; Yoo, Euna ; Murithi, James M ; Luth, Madeline R ; Afanasyev, Pavel ; da Fonseca, Paula C A ; Winzeler, Elizabeth A ; Ng, Caroline L ; Bogyo, Matthew ; Fidock, David A
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2019-06, Vol.15 (6), p.e1007722
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Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study
Author / Creator:McCarthy, James S, Prof ; Lotharius, Julie, PhD ; Rückle, Thomas, PhD ; Chalon, Stephan, MD ; Phillips, Margaret A, Prof ; Elliott, Suzanne, PhD ; Sekuloski, Silvana, PhD ; Griffin, Paul, MD ; Ng, Caroline L, PhD ; Fidock, David A, Prof ; Marquart, Louise, PhD ; Williams, Noelle S, PhD ; Gobeau, Nathalie, PhD ; Bebrevska, Lidiya, PhD ; Rosario, Maria, PhD ; Marsh, Kennan, PhD ; Möhrle, Jörg J, Dr
Publisher:United States: Elsevier Ltd
Journal title:The Lancet infectious diseases, 2017-06, Vol.17 (6), p.626-635
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ArticlesPeer ReviewedFull Text
Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites
Author / Creator:Lee, Andrew H ; Fidock, David A
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-04, Vol.11 (4), p.e0154166-e0154166
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Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
Author / Creator:Adjalley, Sophie H. ; Johnston, Geoffrey L. ; Li, Tao ; Eastman, Richard T. ; Ekland, Eric H. ; Eappen, Abraham G. ; Richman, Adam ; Sim, B. Kim Lee ; Lee, Marcus C. S. ; Hoffman, Stephen L. ; Fidock, David A.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-11, Vol.108 (47), p.18867-18868
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ArticlesPeer ReviewedFull Text
Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families
Author / Creator:Bopp, Selina E R ; Manary, Micah J ; Bright, A Taylor ; Johnston, Geoffrey L ; Dharia, Neekesh V ; Luna, Fabio L ; McCormack, Susan ; Plouffe, David ; McNamara, Case W ; Walker, John R ; Fidock, David A ; Denchi, Eros Lazzerini ; Winzeler, Elizabeth A
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2013-02, Vol.9 (2), p.e1003293
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Fidock, David A

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Fidock, David A

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Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

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Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

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Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance

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Accelerated evolution and spread of multidrug-resistant Plasmodium falciparum takes down the latest first-line antimalarial drug in southeast Asia

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Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

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Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

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Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

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Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

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Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

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Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

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Spiroindolones, a Potent Compound Class for the Treatment of Malaria

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Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages

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A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

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Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

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Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study

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Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites

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Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue

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Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families

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