Characterization and mitigation of gene expression burden in mammalian cells
Characterization and mitigation of gene expression burden in mammalian cells
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Despite recent advances in circuit engineering, the design of genetic networks in mammalian cells is still painstakingly slow and fraught with inexplicable failures. Here, we demonstrate that transiently expressed genes in mammalian cells compete for limited transcriptional and translational resources. This competition results in the coupling of ot...
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Characterization and mitigation of gene expression burden in mammalian cells
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TN_cdi_doaj_primary_oai_doaj_org_article_9e9d2a9d032a4e53a995962e99e67a03
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9e9d2a9d032a4e53a995962e99e67a03
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18392-x
