Mechanism of integrin activation by talin and its cooperation with kindlin
Mechanism of integrin activation by talin and its cooperation with kindlin
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Talin-induced integrin binding to extracellular matrix ligands (integrin activation) is the key step to trigger many fundamental cellular processes including cell adhesion, cell migration, and spreading. Talin is widely known to use its N-terminal head domain (talin-H) to bind and activate integrin, but how talin-H operates in the context of full-l...
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Mechanism of integrin activation by talin and its cooperation with kindlin
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TN_cdi_doaj_primary_oai_doaj_org_article_9ecb7d26bd11431887d1892b5ac0e1a8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9ecb7d26bd11431887d1892b5ac0e1a8
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30117-w