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Mechanism of integrin activation by talin and its cooperation with kindlin

Mechanism of integrin activation by talin and its cooperation with kindlin

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9ecb7d26bd11431887d1892b5ac0e1a8

Mechanism of integrin activation by talin and its cooperation with kindlin

About this item

Full title

Mechanism of integrin activation by talin and its cooperation with kindlin

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2022-04, Vol.13 (1), p.2362-19, Article 2362

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Talin-induced integrin binding to extracellular matrix ligands (integrin activation) is the key step to trigger many fundamental cellular processes including cell adhesion, cell migration, and spreading. Talin is widely known to use its N-terminal head domain (talin-H) to bind and activate integrin, but how talin-H operates in the context of full-l...

Alternative Titles

Full title

Mechanism of integrin activation by talin and its cooperation with kindlin

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_9ecb7d26bd11431887d1892b5ac0e1a8

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9ecb7d26bd11431887d1892b5ac0e1a8

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-022-30117-w

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