Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles
Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Alzheimer’s disease (AD) is defined by intracellular neurofibrillary tangles formed by the microtubule-associated protein tau and extracellular plaques formed by the β-amyloid peptide. AD tau tangles contain a mixture of tau isoforms with either four (4R) or three (3R) microtubule-binding repeats. Here we use solid-state NMR to determine how 4R and...
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Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles
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TN_cdi_doaj_primary_oai_doaj_org_article_9efac7b1629744018fcd3391bfe6243e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9efac7b1629744018fcd3391bfe6243e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30585-0
