Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Type III CRISPR-Cas multisubunit complexes cleave ssRNA and ssDNA. These activities promote the generation of cyclic oligoadenylate (cOA), which activates associated CRISPR-Cas RNases from the Csm/Csx families, triggering a massive RNA decay to provide immunity from genetic invaders. Here we present the structure of
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Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
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TN_cdi_doaj_primary_oai_doaj_org_article_a0552bfd06e54104982c7ac8deb8d5c3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a0552bfd06e54104982c7ac8deb8d5c3
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12244-z
