Complement 3 + -astrocytes are highly abundant in prion diseases, but their abolishment led to an ac...
Complement 3 + -astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Astrogliosis and activation of microglia are hallmarks of prion diseases in humans and animals. Both were viewed to be rather independent events in disease pathophysiology, with proinflammatory microglia considered to be the potential neurotoxic species at late disease stages. Recent investigations have provided substantial evidence that a proinfla...
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Complement 3 + -astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia
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TN_cdi_doaj_primary_oai_doaj_org_article_a08887f6a7ab410092e18ec3fc60b63a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a08887f6a7ab410092e18ec3fc60b63a
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-019-0735-1
