Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with a...
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease
About this item
Full title
Author / Creator
Watt, Stephen , Vasquez, Louella , Walter, Klaudia , Mann, Alice L. , Kundu, Kousik , Chen, Lu , Sims, Ying , Ecker, Simone , Burden, Frances , Farrow, Samantha , Farr, Ben , Iotchkova, Valentina , Elding, Heather , Mead, Daniel , Tardaguila, Manuel , Ponstingl, Hannes , Richardson, David , Datta, Avik , Flicek, Paul , Clarke, Laura , Downes, Kate , Pastinen, Tomi , Fraser, Peter , Frontini, Mattia , Javierre, Biola-Maria , Spivakov, Mikhail and Soranzo, Nicole
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Neutrophils play fundamental roles in innate immune response, shape adaptive immunity, and are a potentially causal cell type underpinning genetic associations with immune system traits and diseases. Here, we profile the binding of myeloid master regulator PU.1 in primary neutrophils across nearly a hundred volunteers. We show that variants associa...
Alternative Titles
Full title
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease
Authors, Artists and Contributors
Author / Creator
Vasquez, Louella
Walter, Klaudia
Mann, Alice L.
Kundu, Kousik
Chen, Lu
Sims, Ying
Ecker, Simone
Burden, Frances
Farrow, Samantha
Farr, Ben
Iotchkova, Valentina
Elding, Heather
Mead, Daniel
Tardaguila, Manuel
Ponstingl, Hannes
Richardson, David
Datta, Avik
Flicek, Paul
Clarke, Laura
Downes, Kate
Pastinen, Tomi
Fraser, Peter
Frontini, Mattia
Javierre, Biola-Maria
Spivakov, Mikhail
Soranzo, Nicole
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a08e861a297c4eba8c835747ae9b90f8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a08e861a297c4eba8c835747ae9b90f8
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22548-8
