SCFβ‐TrCP ubiquitinates CHK1 in an AMPK‐dependent manner in response to glucose deprivation
SCFβ‐TrCP ubiquitinates CHK1 in an AMPK‐dependent manner in response to glucose deprivation
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United States: John Wiley & Sons, Inc
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English
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Publisher
United States: John Wiley & Sons, Inc
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The ATR/CHK1 pathway is a key effector of cellular response to DNA damage and therefore is a critical regulator of genomic stability. While the ATR/CHK1 pathway is often inactivated by mutations, CHK1 itself is rarely mutated in human cancers. Thus, cellular levels of CHK1 likely play a key role in the maintenance of genomic stability and preventin...
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Full title
SCFβ‐TrCP ubiquitinates CHK1 in an AMPK‐dependent manner in response to glucose deprivation
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TN_cdi_doaj_primary_oai_doaj_org_article_a11455f9cf8e4348a93be77a7fd8550a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a11455f9cf8e4348a93be77a7fd8550a
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ISSN
1574-7891
E-ISSN
1878-0261
DOI
10.1002/1878-0261.12403
