Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
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Beatty, Alexander , Singh, Tanu , Tyurina, Yulia Y. , Tyurin, Vladimir A. , Samovich, Svetlana , Nicolas, Emmanuelle , Maslar, Kristen , Zhou, Yan , Cai, Kathy Q. , Tan, Yinfei , Doll, Sebastian , Conrad, Marcus , Subramanian, Aravind , Bayır, Hülya , Kagan, Valerian E. , Rennefahrt, Ulrike and Peterson, Jeffrey R.
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Ferroptosis is associated with lipid hydroperoxides generated by the oxidation of polyunsaturated acyl chains. Lipid hydroperoxides are reduced by glutathione peroxidase 4 (GPX4) and GPX4 inhibitors induce ferroptosis. However, the therapeutic potential of triggering ferroptosis in cancer cells with polyunsaturated fatty acids is unknown. Here, we...
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Full title
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
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TN_cdi_doaj_primary_oai_doaj_org_article_a15fa8f172aa4a2c98e5449033292272
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a15fa8f172aa4a2c98e5449033292272
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22471-y
