Adenine base editors induce off-target structure variations in mouse embryos and primary human T cel...
Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
The safety of CRISPR-based gene editing methods is of the utmost priority in clinical applications. Previous studies have reported that Cas9 cleavage induced frequent aneuploidy in primary human T cells, but whether cleavage-mediated editing of base editors would generate off-target structure variations remains unknown. Here, we investigate the pot...
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Full title
Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells
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TN_cdi_doaj_primary_oai_doaj_org_article_a173f9a0e0c44725899cd86c3aaab2fd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a173f9a0e0c44725899cd86c3aaab2fd
Other Identifiers
ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-024-03434-0
