Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients
Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Maintenance of bacterial cell shape and resistance to osmotic stress by the peptidoglycan (PG) renders PG biosynthetic enzymes and precursors attractive targets for combating bacterial infections. Here, by applying native mass spectrometry, we elucidate the effects of lipid substrates on the PG membrane enzymes MraY, MurG, and MurJ. We show that di...
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Full title
Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients
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TN_cdi_doaj_primary_oai_doaj_org_article_a1a15d916c894fcdb85734251559a178
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a1a15d916c894fcdb85734251559a178
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-29836-x
