Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summa...
Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics
About this item
Full title
Author / Creator
Miao, Jiacheng , Guo, Hanmin , Song, Gefei , Zhao, Zijie , Hou, Lin and Lu, Qiongshi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of Europeans are known to have substantially reduced predictive accuracy in non-European populations, limiting their clinical utility and raising concerns about health disparities across ancestral populations. Here, we introduce a statistical framework named X-Wing t...
Alternative Titles
Full title
Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a1e062fda2fc420eb11d06392cf93f52
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a1e062fda2fc420eb11d06392cf93f52
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36544-7
