Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Infiltrative growth is a major cause of high lethality of malignant brain tumors such as glioblastoma (GBM). We show here that GBM cells upregulate guidance receptor Plexin-B2 to gain invasiveness. Deletion of Plexin-B2 in GBM stem cells limited tumor spread and shifted invasion paths from axon fiber tracts to perivascular routes. On a cellular lev...
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Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
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TN_cdi_doaj_primary_oai_doaj_org_article_a21043ef77f3429eb2a9321d811b140e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a21043ef77f3429eb2a9321d811b140e
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-021-01667-4
