SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
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Author / Creator
Gassen, Nils C. , Papies, Jan , Bajaj, Thomas , Emanuel, Jackson , Dethloff, Frederik , Chua, Robert Lorenz , Trimpert, Jakob , Heinemann, Nicolas , Niemeyer, Christine , Weege, Friderike , Hönzke, Katja , Aschman, Tom , Heinz, Daniel E. , Weckmann, Katja , Ebert, Tim , Zellner, Andreas , Lennarz, Martina , Wyler, Emanuel , Schroeder, Simon , Richter, Anja , Niemeyer, Daniela , Hoffmann, Karen , Meyer, Thomas F. , Heppner, Frank L. , Corman, Victor M. , Landthaler, Markus , Hocke, Andreas C. , Morkel, Markus , Osterrieder, Nikolaus , Conrad, Christian , Eils, Roland , Radbruch, Helena , Giavalisco, Patrick , Drosten, Christian and Müller, Marcel A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces autophagy. Accordingly, compound-driven induction...
Alternative Titles
Full title
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Authors, Artists and Contributors
Author / Creator
Papies, Jan
Bajaj, Thomas
Emanuel, Jackson
Dethloff, Frederik
Chua, Robert Lorenz
Trimpert, Jakob
Heinemann, Nicolas
Niemeyer, Christine
Weege, Friderike
Hönzke, Katja
Aschman, Tom
Heinz, Daniel E.
Weckmann, Katja
Ebert, Tim
Zellner, Andreas
Lennarz, Martina
Wyler, Emanuel
Schroeder, Simon
Richter, Anja
Niemeyer, Daniela
Hoffmann, Karen
Meyer, Thomas F.
Heppner, Frank L.
Corman, Victor M.
Landthaler, Markus
Hocke, Andreas C.
Morkel, Markus
Osterrieder, Nikolaus
Conrad, Christian
Eils, Roland
Radbruch, Helena
Giavalisco, Patrick
Drosten, Christian
Müller, Marcel A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a210cbf8766241fd8d824076b3b287b5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a210cbf8766241fd8d824076b3b287b5
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24007-w
