Synthesis of phthalazine-based derivatives as selective anti-breast cancer agents through EGFR-media...
Synthesis of phthalazine-based derivatives as selective anti-breast cancer agents through EGFR-mediated apoptosis: in vitro and in silico studies
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Cham: Springer International Publishing
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Language
English
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Cham: Springer International Publishing
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Contents
The parent 2-(4-benzyl-1-oxophthalazin-2(1
H
)-yl)-acetohydrazide
(4)
has twenty-nine compounds. The starting material for their corresponding mono, dipeptides and reactions with active methylene compounds were produced by chemoselective
N
-alkylation of 4-Benzyl-2
H
-phthalazin-1-one
(2)
with ethyl chloroacetate to af...
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Full title
Synthesis of phthalazine-based derivatives as selective anti-breast cancer agents through EGFR-mediated apoptosis: in vitro and in silico studies
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TN_cdi_doaj_primary_oai_doaj_org_article_a272033e9d584ae894806609fd5e0795
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a272033e9d584ae894806609fd5e0795
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ISSN
2661-801X
E-ISSN
2661-801X
DOI
10.1186/s13065-023-00995-2
