10 Enhancing the therapeutic responses of anti-human CCR8 mAbs utilizing the fully humanized CCR8 kn...
10 Enhancing the therapeutic responses of anti-human CCR8 mAbs utilizing the fully humanized CCR8 knockin mice
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Author / Creator
Li, Yi , Ma, Hechun , Ci, Lei , Lian, Kaixia , Liu, Demi X , Fei, Jian , Sun, Ruilin and He, Daniel X
Publisher
London: BMJ Publishing Group Ltd
Journal title
Language
English
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Publisher
London: BMJ Publishing Group Ltd
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Contents
BackgroundDepletion of tumor-resident CCR8+ Treg cells has been demonstrated remarkable antitumor effects. A few hCCR8-targeted therapeutic antibodies have been developed and are now undergone clinical testing in patients with advanced or metastatic solid tumors. However, the challenge remains in preclinical evaluation for human-specific CCR8 mAbs...
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Full title
10 Enhancing the therapeutic responses of anti-human CCR8 mAbs utilizing the fully humanized CCR8 knockin mice
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TN_cdi_doaj_primary_oai_doaj_org_article_a2afc87b8b5548f8a31a004a90065d8d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a2afc87b8b5548f8a31a004a90065d8d
Other Identifiers
E-ISSN
2051-1426
DOI
10.1136/jitc-2023-SITC2023.0010
