Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoa...
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The inhibitory action of fifteen benzyloxy
ortho
/
para
-substituted chalcones (
B1-B15
) was evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO-B isoform more potently than hMAO-A. Furthermore, the majority of the molecules showed strong inhibitory actions against hMAO-B at 10 μM level with resid...
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Full title
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
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TN_cdi_doaj_primary_oai_doaj_org_article_a2bfe60187b04ffe9e2cd48d14cd228e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a2bfe60187b04ffe9e2cd48d14cd228e
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-26929-x
