Osmotically balanced, large unilamellar liposomes that enable sustained bupivacaine release for prol...
Osmotically balanced, large unilamellar liposomes that enable sustained bupivacaine release for prolonged pain relief in in vivo rat models
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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To efficiently prolong analgesic effects, we developed osmotically balanced, large unilamellar liposomes (~ 6 μm in diameter) in which highly concentrated bupivacaine (up to 30 mg/mL) was encapsulated, and their sustained bupivacaine release was highly effective in relieving postoperative pain over 24 h in a rat model. Our reverse-phase evaporation...
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Osmotically balanced, large unilamellar liposomes that enable sustained bupivacaine release for prolonged pain relief in in vivo rat models
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TN_cdi_doaj_primary_oai_doaj_org_article_a3b063f74f824d649d0f2aa8312b2a9f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a3b063f74f824d649d0f2aa8312b2a9f
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-91624-2
