An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to gl...
An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Oncolytic herpes simplex virus-1 is capable of lysing tumor cells while alerting the immune system. CD47, in collaboration with SIRPα, represents an important immune checkpoint to inhibit phagocytosis by innate immune cells. Here we show locoregional control of glioblastoma by an oncolytic herpes virus expressing a full-length anti(α)-human CD47 Ig...
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An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
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TN_cdi_doaj_primary_oai_doaj_org_article_a3ded407a8e84ba2981a8d05e9d3ad5a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a3ded407a8e84ba2981a8d05e9d3ad5a
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26003-6
