Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of vi...
Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles
About this item
Full title
Author / Creator
Wang, Daning , Liu, Xinlin , Wei, Minxi , Qian, Ciying , Song, Shuo , Chen, Jie , Wang, Zhiping , Xu, Qin , Yang, Yurou , He, Maozhou , Chi, Xin , Huang, Shiwen , Li, Tingting , Kong, Zhibo , Zheng, Qingbing , Yu, Hai , Wang, Yingbin , Zhao, Qinjian , Zhang, Jun , Xia, Ningshao , Gu, Ying and Li, Shaowei
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The capsid of human papillomavirus (HPV) spontaneously arranges into a T = 7 icosahedral particle with 72 L1 pentameric capsomeres associating via disulfide bonds between Cys175 and Cys428. Here, we design a capsomere-hybrid virus-like particle (chVLP) to accommodate multiple types of L1 pentamers by the reciprocal assembly of single C175A and C428...
Alternative Titles
Full title
Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a48ad75cb64149f78c08387b5f6a5505
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a48ad75cb64149f78c08387b5f6a5505
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16639-1
