α-Synuclein oligomers form by secondary nucleation
α-Synuclein oligomers form by secondary nucleation
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Author / Creator
Xu, Catherine K. , Meisl, Georg , Andrzejewska, Ewa A. , Krainer, Georg , Dear, Alexander J. , Castellana-Cruz, Marta , Turi, Soma , Edu, Irina A. , Vivacqua, Giorgio , Jacquat, Raphaël P. B. , Arter, William E. , Spillantini, Maria Grazia , Vendruscolo, Michele , Linse, Sara and Knowles, Tuomas P. J.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Oligomeric species arising during the aggregation of
α
-synuclein are implicated as a major source of toxicity in Parkinson’s disease, and thus a major potential drug target. However, both their mechanism of formation and role in aggregation are largely unresolved. Here we show that, at physiological pH and in the absence of lipid membranes,<...
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Full title
α-Synuclein oligomers form by secondary nucleation
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TN_cdi_doaj_primary_oai_doaj_org_article_a4d1104eb0184ade8af0b5e5b4fb8983
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a4d1104eb0184ade8af0b5e5b4fb8983
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-50692-4
