Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despi...
Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex interactions: the potential role of astrocytes
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Switzerland: Frontiers Research Foundation
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English
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Switzerland: Frontiers Research Foundation
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Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-6162 (5 mg/kg), which has a high affinity for Sigma1R, significantly increased the density of accumbal shell D2R-Sigma1R and A2AR-D2R heteroreceptor complexes following cocaine self-administration.
studies using the A2AR agonist CGS21680 also suggested the exi...
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Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex interactions: the potential role of astrocytes
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TN_cdi_doaj_primary_oai_doaj_org_article_a51533e3ab2b4ca094a860cf75cf665a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a51533e3ab2b4ca094a860cf75cf665a
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ISSN
1662-5099
E-ISSN
1662-5099
DOI
10.3389/fnmol.2023.1106765
