Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and...
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
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Publisher
England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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Cellular senescence, a hallmark of aging, has been implicated in Alzheimer's disease (AD) pathogenesis. Cholesterol accumulation is known to drive cellular senescence; however, its underlying mechanisms are not fully understood. ATP-binding cassette transporter A1 (ABCA1) plays an important role in cholesterol homeostasis, and its expression and tr...
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Full title
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
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TN_cdi_doaj_primary_oai_doaj_org_article_a54f42427b0941998a14c6fa6eba3077
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a54f42427b0941998a14c6fa6eba3077
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-025-00802-7
