Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models
Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models
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Author / Creator
Havel, Václav , Kruegel, Andrew C. , Bechand, Benjamin , McIntosh, Scot , Stallings, Leia , Hodges, Alana , Wulf, Madalee G. , Nelson, Mel , Hunkele, Amanda , Ansonoff, Michael , Pintar, John E. , Hwu, Christopher , Ople, Rohini S. , Abi-Gerges, Najah , Zaidi, Saheem A. , Katritch, Vsevolod , Yang, Mu , Javitch, Jonathan A. , Majumdar, Susruta , Hemby, Scott E. and Sames, Dalibor
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Ibogaine and its main metabolite noribogaine provide important molecular prototypes for markedly different treatment of substance use disorders and co-morbid mental health illnesses. However, these compounds present a cardiac safety risk and a highly complex molecular mechanism. We introduce a class of iboga alkaloids – termed oxa-iboga – defined a...
Alternative Titles
Full title
Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models
Authors, Artists and Contributors
Author / Creator
Kruegel, Andrew C.
Bechand, Benjamin
McIntosh, Scot
Stallings, Leia
Hodges, Alana
Wulf, Madalee G.
Nelson, Mel
Hunkele, Amanda
Ansonoff, Michael
Pintar, John E.
Hwu, Christopher
Ople, Rohini S.
Abi-Gerges, Najah
Zaidi, Saheem A.
Katritch, Vsevolod
Yang, Mu
Javitch, Jonathan A.
Majumdar, Susruta
Hemby, Scott E.
Sames, Dalibor
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a56405d25d8040d397ce8623055b504b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a56405d25d8040d397ce8623055b504b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-51856-y
