Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy
Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anti-cancer targets. Using small cell lung cancer (SCLC) as a model, we demonstrated the presence of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-X
L
or MCL-1, which correlated with the respective protein expression ratio. ABT-263 (nav...
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Full title
Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy
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TN_cdi_doaj_primary_oai_doaj_org_article_a5d834b769b2400b86f4baf0dda324e5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a5d834b769b2400b86f4baf0dda324e5
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms16078
