Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy effi...
Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy efficacy in dMMR/MSI-H gastric adenocarcinoma
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Author / Creator
Wang, Zhenghang , Wang, Xinyu , Xu, Yu , Li, Jian , Zhang, Xiaotian , Peng, Zhi , Hu, Yajie , Zhao, Xinya , Dong, Kun , Zhang, Bei , Gao, Chan , Zhao, Xiaochen , Chen, Hui , Cai, Jinping , Bai, Yuezong , Sun, Yu and Shen, Lin
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
A significant subset of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastric adenocarcinomas (GAC) are resistant to immune checkpoint inhibitors (ICIs), yet the underlying mechanism remains largely unknown. We sought to investigate the genomic correlates of the density of tumor-infiltrating immune cells (DTICs) and prima...
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Full title
Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy efficacy in dMMR/MSI-H gastric adenocarcinoma
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a78e631447fb4ae89f9a47b6ed404f64
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a78e631447fb4ae89f9a47b6ed404f64
Other Identifiers
ISSN
1741-7015
E-ISSN
1741-7015
DOI
10.1186/s12916-022-02327-y
