Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
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Author / Creator
Yampolsky, Pessah , Koenen, Michael , Mosqueira, Matias , Geschwill, Pascal , Nauck, Sebastian , Witzenberger, Monika , Seyler, Claudia , Fink, Thomas , Kruska, Mathieu , Bruehl, Claus , Schwoerer, Alexander P. , Ehmke, Heimo , Fink, Rainer H. A. , Draguhn, Andreas , Thomas, Dierk , Katus, Hugo A. and Schweizer, Patrick A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
HCN channels underlie the depolarizing funny current (I
f
) that contributes importantly to cardiac pacemaking. I
f
is upregulated in failing and infarcted hearts, but its implication in disease mechanisms remained unresolved. We generated transgenic
mice
(
HCN4
tg/wt
) to assess functional consequences of
HCN4
over...
Alternative Titles
Full title
Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
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Author / Creator
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TN_cdi_doaj_primary_oai_doaj_org_article_a8006cdc1e634c8e922f247e1bb32c74
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a8006cdc1e634c8e922f247e1bb32c74
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11261-2
