Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein
Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein
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Publisher
England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
The intricate lattice of Gn and Gc glycoprotein spike complexes on the hantavirus envelope facilitates host-cell entry and is the primary target of the neutralizing antibody-mediated immune response. Through study of a neutralizing monoclonal antibody termed mAb P-4G2, which neutralizes the zoonotic pathogen Puumala virus (PUUV), we provide a molec...
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Full title
Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein
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TN_cdi_doaj_primary_oai_doaj_org_article_a811ae9d2ec64aa9a3922c1b8fc9e42d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a811ae9d2ec64aa9a3922c1b8fc9e42d
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.58242
