Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth
Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth
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Publisher
England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Contents
Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycle genes. Cardiac myocytes (CMs) accumulate heterochromatin during differentiation and demethylation of H3K9me3 inhibits cell cycle gene silen...
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Full title
Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth
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TN_cdi_doaj_primary_oai_doaj_org_article_a8976ee3773e4a23bd563d67ccc34511
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a8976ee3773e4a23bd563d67ccc34511
Other Identifiers
ISSN
1756-8935
E-ISSN
1756-8935
DOI
10.1186/s13072-018-0187-z
