PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerabi...
PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma
About this item
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Author / Creator
Wang, Kui , Luo, Li , Fu, Shuyue , Wang, Mao , Wang, Zihao , Dong, Lixia , Wu, Xingyun , Dai, Lunzhi , Peng, Yong , Shen, Guobo , Chen, Hai-Ning , Nice, Edouard Collins , Wei, Xiawei and Huang, Canhua
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Here, using integrative metabolomics and transcriptomics analyses, we show a heterogeneity between metabolite and transcript profiles. Specifically, the level of serine in hepatocellular carcinoma (HCC) tissues is increased, whereas th...
Alternative Titles
Full title
PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a8cf977e10a64602a434646123cf3d01
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a8cf977e10a64602a434646123cf3d01
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36708-5
