Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
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England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Interactions of developing T cells with Aire
medullary thymic epithelial cells expressing high levels of MHCII molecules (mTEC
) are critical for the induction of central tolerance in the thymus. In turn, thymocytes regulate the cellularity of Aire
mTEC
. However, it remains unknown whether thymocytes control the precursors of Aire
m...
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Full title
Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
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TN_cdi_doaj_primary_oai_doaj_org_article_a967244e4d8746a2a75d6f0db2491acc
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a967244e4d8746a2a75d6f0db2491acc
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.69982
