GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen re...
GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance
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England: eLife Sciences Publications Ltd
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Language
English
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England: eLife Sciences Publications Ltd
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Contents
Genomic amplification of the androgen receptor (AR) is an established mechanism of antiandrogen resistance in prostate cancer. Here, we show that the magnitude of AR signaling output, independent of AR genomic alteration or expression level, also contributes to antiandrogen resistance, through upregulation of the coactivator GREB1. We demonstrate 1...
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GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance
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TN_cdi_doaj_primary_oai_doaj_org_article_a9ce9b1a721845688d664f179362cf94
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a9ce9b1a721845688d664f179362cf94
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.41913
