The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of del...
The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Double-strand breaks in the mitochondrial DNA (mtDNA) result in the formation of linear fragments that are rapidly degraded. However, the identity of the nuclease(s) performing this function is not known. We found that the exonuclease function of the mtDNA polymerase gamma (POLG) is required for this rapid degradation of mtDNA fragments. POLG is re...
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Full title
The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
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TN_cdi_doaj_primary_oai_doaj_org_article_aa5ad2b48a7642f3848faf16ada6efe3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aa5ad2b48a7642f3848faf16ada6efe3
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04895-1
