Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold
Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold
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Publisher
England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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Down syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among their complex clinical features, including musculoskeletal, neurological, and cardiovascular disabilities, individuals with DS have an increased risk of developing progressive dementia and early-onset Alzheimer's disease (AD). This dementia is attributed to t...
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Full title
Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold
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TN_cdi_doaj_primary_oai_doaj_org_article_aac87a63fb79463b9e1a637cad62d4a9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aac87a63fb79463b9e1a637cad62d4a9
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-024-01806-y
