A small molecule HIF-1α stabilizer that accelerates diabetic wound healing
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Impaired wound healing and ulcer complications are a leading cause of death in diabetic patients. In this study, we report the design and synthesis of a cyclometalated iridium(III) metal complex
1a
as a stabilizer of hypoxia-inducible factor-1α (HIF-1α). In vitro biophysical and cellular analyses demonstrate that this compound binds to Von Hi...
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Full title
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing
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TN_cdi_doaj_primary_oai_doaj_org_article_ab01c58730bb45109483db19c65692d4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ab01c58730bb45109483db19c65692d4
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23448-7
