Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activ...
Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Cytosine base editors (CBEs) enable efficient, programmable reversion of T•A to C•G point mutations in the human genome. Recently, cytosine base editors with rAPOBEC1 were reported to induce unguided cytosine deamination in genomic DNA and cellular RNA. Here we report eight next-generation CBEs (BE4 with either RrA3F [wt, F130L], AmAPOBEC1, SsAPOBE...
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Full title
Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
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TN_cdi_doaj_primary_oai_doaj_org_article_ab50974242654c18950c59b5e285c447
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ab50974242654c18950c59b5e285c447
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15887-5
