Rho GTPase activity crosstalk mediated by Arhgef11 and Arhgef12 coordinates cell protrusion-retracti...
Rho GTPase activity crosstalk mediated by Arhgef11 and Arhgef12 coordinates cell protrusion-retraction cycles
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Rho GTPases play a key role in the spatio-temporal coordination of cytoskeletal dynamics during cell migration. Here, we directly investigate crosstalk between the major Rho GTPases Rho, Rac and Cdc42 by combining rapid activity perturbation with activity measurements in mammalian cells. These studies reveal that Rac stimulates Rho activity. Direct...
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Rho GTPase activity crosstalk mediated by Arhgef11 and Arhgef12 coordinates cell protrusion-retraction cycles
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TN_cdi_doaj_primary_oai_doaj_org_article_ab65325bb46f4cc898719fb2bad4d6f9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ab65325bb46f4cc898719fb2bad4d6f9
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-43875-y
