Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alz...
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
About this item
Full title
Author / Creator
Spangenberg, Elizabeth , Severson, Paul L. , Hohsfield, Lindsay A. , Crapser, Joshua , Zhang, Jiazhong , Burton, Elizabeth A. , Zhang, Ying , Spevak, Wayne , Lin, Jack , Phan, Nicole Y. , Habets, Gaston , Rymar, Andrey , Tsang, Garson , Walters, Jason , Nespi, Marika , Singh, Parmveer , Broome, Stephanie , Ibrahim, Prabha , Zhang, Chao , Bollag, Gideon , West, Brian L. , Green, Kim N. and Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Many risk genes for the development of Alzheimer’s disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival. We designed and synthesized a highly selective brain-penetrant CSF1R inhibitor (PLX5622) allowing for extended and specific microg...
Alternative Titles
Full title
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
Authors, Artists and Contributors
Author / Creator
Severson, Paul L.
Hohsfield, Lindsay A.
Crapser, Joshua
Zhang, Jiazhong
Burton, Elizabeth A.
Zhang, Ying
Spevak, Wayne
Lin, Jack
Phan, Nicole Y.
Habets, Gaston
Rymar, Andrey
Tsang, Garson
Walters, Jason
Nespi, Marika
Singh, Parmveer
Broome, Stephanie
Ibrahim, Prabha
Zhang, Chao
Bollag, Gideon
West, Brian L.
Green, Kim N.
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ab83dec7482d44a28b96b168ea75f0ff
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ab83dec7482d44a28b96b168ea75f0ff
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11674-z
