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ArticlesPeer ReviewedFull Text
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
Author / Creator:Spangenberg, Elizabeth ; Severson, Paul L. ; Hohsfield, Lindsay A. ; Crapser, Joshua ; Zhang, Jiazhong ; Burton, Elizabeth A. ; Zhang, Ying ; Spevak, Wayne ; Lin, Jack ; Phan, Nicole Y. ; Habets, Gaston ; Rymar, Andrey ; Tsang, Garson ; Walters, Jason ; Nespi, Marika ; Singh, Parmveer ; Broome, Stephanie ; Ibrahim, Prabha ; Zhang, Chao ; Bollag, Gideon ; West, Brian L. ; Green, Kim N.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-08, Vol.10 (1), p.3758-21, Article 3758
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ArticlesPeer ReviewedFull Text
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
Author / Creator:Bollag, Gideon ; Hirth, Peter ; Tsai, James ; Zhang, Jiazhong ; Ibrahim, Prabha N. ; Cho, Hanna ; Spevak, Wayne ; Zhang, Chao ; Zhang, Ying ; Habets, Gaston ; Burton, Elizabeth A. ; Wong, Bernice ; Tsang, Garson ; West, Brian L. ; Powell, Ben ; Shellooe, Rafe ; Marimuthu, Adhirai ; Nguyen, Hoa ; Zhang, Kam Y. J. ; Artis, Dean R. ; Schlessinger, Joseph ; Su, Fei ; Higgins, Brian ; Iyer, Raman ; D’Andrea, Kurt ; Koehler, Astrid ; Stumm, Michael ; Lin, Paul S. ; Lee, Richard J. ; Grippo, Joseph ; Puzanov, Igor ; Kim, Kevin B. ; Ribas, Antoni ; McArthur, Grant A. ; Sosman, Jeffrey A. ; Chapman, Paul B. ; Flaherty, Keith T. ; Xu, Xiaowei ; Nathanson, Katherine L. ; Nolop, Keith
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2010-09, Vol.467 (7315), p.596-599
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Newsletter articlesFull Text
Ibrahim Prabha N, Zhang Chao, Spevak Wayne, Zhang Jiazhong, Wu Guoxian, Lin Jack, Cho Hanna, Nespi Marika, Shi Songyuan, Ewing Todd and Zhang Ying Submit Patent Application for Compounds and Methods f...
Publisher:New Delhi: Pedia Content Solutions Pvt. Ltd
Journal title:Global IP News. Pharmaceutical Patent News, 2014
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ArticlesPeer ReviewedFull Text
Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor
Author / Creator:Zhang, Chao ; Ibrahim, Prabha N. ; Zhang, Jiazhong ; Burton, Elizabeth A. ; Habets, Gaston ; Zhang, Ying ; Powell, Ben ; West, Brian L. ; Matusow, Bernice ; Tsang, Garson ; Shellooe, Rafe ; Carias, Heidi ; Nguyen, Hoa ; Marimuthu, Adhirai ; Zhang, Kam Y. J. ; Oh, Angela ; Bremer, Ryan ; Hurt, Clarence R. ; Artis, Dean R. ; Wu, Guoxian ; Nespi, Marika ; Spevak, Wayne ; Lin, Paul ; Nolop, Keith ; Hirth, Peter ; Tesch, Greg H. ; Bollag, Gideon
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-04, Vol.110 (14), p.5689-5694
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Newsletter articlesFull Text
WIPO PUBLISHES PATENT OF PLEXXIKON, IBRAHIM PRABHA N., ZHANG CHAO, SPEVAK WAYNE, ZHANG JIAZHONG, WU GUOXIAN, LIN JACK, CHO HANNA, NESPI MARIKA, SHI SONGYUAN, EWING TODD, ZHANG YING FOR "COMPOUNDS AND...
Publisher:Washington, D.C: HT Digital Streams Limited
Journal title:US Fed News Service, Including US State News, 2012
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ArticlesPeer ReviewedFull Text
Direct Colorimetric Detection of a Receptor-Ligand Interaction by a Polymerized Bilayer Assembly
Author / Creator:Charych, Deborah H. ; Nagy, Jon O. ; Spevak, Wayne ; Bednarski, Mark D.
Publisher:Washington, DC: American Society for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 1993-07, Vol.261 (5121), p.585-588
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ArticlesPeer ReviewedFull Text
A Novel Small Molecule That Directly Sensitizes the Insulin Receptor In Vitro and In Vivo
Author / Creator:VARA PRASAD MANCHEM ; GOLDFINE, Ira D ; VILLAR, Hugo O ; WICK, Michael M ; KOZLOWSKI, Michael R ; KOHANSKI, Ronald A ; CRISTOBAL, Cristina P ; LUM, Robert T ; SCHOW, Steven R ; SHI, Songyuan ; SPEVAK, Wayne R ; LABORDE, Edgardo ; TOAVS, Deborah K
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2001-04, Vol.50 (4), p.824-830
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ArticlesPeer ReviewedFull Text
RAF inhibitors that evade paradoxical MAPK pathway activation
Author / Creator:Zhang, Chao ; Spevak, Wayne ; Zhang, Ying ; Burton, Elizabeth A. ; Ma, Yan ; Habets, Gaston ; Zhang, Jiazhong ; Lin, Jack ; Ewing, Todd ; Matusow, Bernice ; Tsang, Garson ; Marimuthu, Adhirai ; Cho, Hanna ; Wu, Guoxian ; Wang, Weiru ; Fong, Daniel ; Nguyen, Hoa ; Shi, Songyuan ; Womack, Patrick ; Nespi, Marika ; Shellooe, Rafe ; Carias, Heidi ; Powell, Ben ; Light, Emily ; Sanftner, Laura ; Walters, Jason ; Tsai, James ; West, Brian L. ; Visor, Gary ; Rezaei, Hamid ; Lin, Paul S. ; Nolop, Keith ; Ibrahim, Prabha N. ; Hirth, Peter ; Bollag, Gideon
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-10, Vol.526 (7574), p.583-586
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ArticlesPeer ReviewedFull Text
Activation of Insulin Signal Transduction by Novel Compounds
Author / Creator:MANCHEM, PRASAD ; JOMORI, TAKAHITO ; SPEVAK, WAYNE R ; SHI, SONGYUAN ; ROBINSON, LOUISE ; CHAN, JULIE T ; LE, PHUONG N ; TOAVS, DEBORAH K ; LEE, SANDRA K ; LUM, ROBERT T ; SCHOW, STEVEN R ; KOZLOWSKI, MICHAEL R
Publisher:American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 1999-05, Vol.48 (5), p.SA335
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ReportsFull Text
RAF inhibitors that evade paradoxical MAPK pathway activation
Author / Creator:Zhang, Chao ; Spevak, Wayne ; Zhang, Ying ; Burton, Elizabeth A ; Ma, Yan ; Habets, Gaston ; Zhang, Jiazhong ; Lin, Jack ; Ewing, Todd ; Matusow, Bernice ; Tsang, Carson ; Marimuthu, Adhirai ; Cho, Hanna ; Wu, Guoxian ; Wang, Weiru ; Fong, Daniel ; Nguyen, Hoa ; Shi, Songyuan ; Womack, Patrick ; Nespi, Marika ; Shellooe, Rafe ; Carias, Heidi ; Powell, Ben ; Light, Emily ; Sanftner, Laura ; Walters, Jason ; Tsai, James ; West, Brian L ; Visor, Gary ; Rezaei, Hamid ; Lin, Paul S ; Nolop, Keith ; Ibrahim, Prabha N ; Hirth, Peter ; Bollag, Gideon
Publisher:Nature Publishing Group
Journal title:Nature, 2015, p.583
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ReportsFull Text
RAF inhibitors that evade paradoxical MAPK pathway activation
Author / Creator:Zhang, Chao ; Spevak, Wayne ; Zhang, Ying ; Burton, Elizabeth A ; Ma, Yan ; Habets, Gaston ; Zhang, Jiazhong ; Lin, Jack ; Ewing, Todd ; Matusow, Bernice ; Tsang, Carson ; Marimuthu, Adhirai ; Cho, Hanna ; Wu, Guoxian ; Wang, Weiru ; Fong, Daniel ; Nguyen, Hoa ; Shi, Songyuan ; Womack, Patrick ; Nespi, Marika ; Shellooe, Rafe ; Carias, Heidi ; Powell, Ben ; Light, Emily ; Sanftner, Laura ; Walters, Jason ; Tsai, James ; West, Brian L ; Visor, Gary ; Rezaei, Hamid ; Lin, Paul S ; Nolop, Keith ; Ibrahim, Prabha N ; Hirth, Peter ; Bollag, Gideon
Publisher:Nature Publishing Group
Journal title:Nature, 2015, p.583
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Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

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Ibrahim Prabha N, Zhang Chao, Spevak Wayne, Zhang Jiazhong, Wu Guoxian, Lin Jack, Cho Hanna, Nespi Marika, Shi Songyuan, Ewing Todd and Zhang Ying Submit Patent Application for Compounds and Methods f...

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Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor

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WIPO PUBLISHES PATENT OF PLEXXIKON, IBRAHIM PRABHA N., ZHANG CHAO, SPEVAK WAYNE, ZHANG JIAZHONG, WU GUOXIAN, LIN JACK, CHO HANNA, NESPI MARIKA, SHI SONGYUAN, EWING TODD, ZHANG YING FOR "COMPOUNDS AND...

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Direct Colorimetric Detection of a Receptor-Ligand Interaction by a Polymerized Bilayer Assembly

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A Novel Small Molecule That Directly Sensitizes the Insulin Receptor In Vitro and In Vivo

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RAF inhibitors that evade paradoxical MAPK pathway activation

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Activation of Insulin Signal Transduction by Novel Compounds

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RAF inhibitors that evade paradoxical MAPK pathway activation

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RAF inhibitors that evade paradoxical MAPK pathway activation

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