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HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distin...

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distin...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ac15869e948c47c2b1fd101eeab5a88a

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

About this item

Full title

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

Publisher

England: eLife Sciences Publications Ltd

Journal title

eLife, 2018-03, Vol.7

Language

English

Formats

Publication information

Publisher

England: eLife Sciences Publications Ltd

More information

Scope and Contents

Contents

HIV-1 entry into cells requires binding of the viral envelope glycoprotein (Env) to receptor CD4 and coreceptor. Imaging of individual Env molecules on native virions shows Env trimers to be dynamic, spontaneously transitioning between three distinct well-populated conformational states: a pre-triggered Env (State 1), a default intermediate (State...

Alternative Titles

Full title

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_ac15869e948c47c2b1fd101eeab5a88a

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ac15869e948c47c2b1fd101eeab5a88a

Other Identifiers

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.34271

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