A Translation-Independent Directed Evolution Strategy to Engineer Aminoacyl-tRNA Synthetases
A Translation-Independent Directed Evolution Strategy to Engineer Aminoacyl-tRNA Synthetases
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Publisher
United States: American Chemical Society
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Language
English
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Publisher
United States: American Chemical Society
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Contents
Using directed evolution, aminoacyl-tRNA synthetases (aaRSs) have been engineered to incorporate numerous noncanonical amino acids (ncAAs). Until now, the selection of such novel aaRS mutants has relied on the expression of a selectable reporter protein. However, such translation-dependent selections are incompatible with exotic monomers that are s...
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Full title
A Translation-Independent Directed Evolution Strategy to Engineer Aminoacyl-tRNA Synthetases
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TN_cdi_doaj_primary_oai_doaj_org_article_ac17ef1c226146e99cb0921bd5b4b94a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ac17ef1c226146e99cb0921bd5b4b94a
Other Identifiers
ISSN
2374-7943
E-ISSN
2374-7951
DOI
10.1021/acscentsci.3c01557
