CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
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Author / Creator
Wu, Xingxin , Wu, Xudong , Ma, Yuxiang , Shao, Fenli , Tan, Yang , Tan, Tao , Gu, Liyun , Zhou, Yang , Sun, Beicheng , Sun, Yang , Wu, Xuefeng and Xu, Qiang
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Excessive activation of hepatic stellate cells (HSCs) is a key step in liver fibrogenesis. Here we report that CUG-binding protein 1 (CUGBP1) expression is elevated in HSCs and positively correlates with liver fibrosis severity in human liver biopsies. Transforming growth factor-beta (TGF-β) selectively increases CUGBP1 expression in cultured HSCs...
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Full title
CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_ac7fe1e98e6e47c8a1df5add0cbe24dc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ac7fe1e98e6e47c8a1df5add0cbe24dc
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms13498