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CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ac7fe1e98e6e47c8a1df5add0cbe24dc

CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

About this item

Full title

CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2016-11, Vol.7 (1), p.13498-13498, Article 13498

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Excessive activation of hepatic stellate cells (HSCs) is a key step in liver fibrogenesis. Here we report that CUG-binding protein 1 (CUGBP1) expression is elevated in HSCs and positively correlates with liver fibrosis severity in human liver biopsies. Transforming growth factor-beta (TGF-β) selectively increases CUGBP1 expression in cultured HSCs...

Alternative Titles

Full title

CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_ac7fe1e98e6e47c8a1df5add0cbe24dc

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ac7fe1e98e6e47c8a1df5add0cbe24dc

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/ncomms13498

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