CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
About this item
Full title
Author / Creator
Wu, Xingxin , Wu, Xudong , Ma, Yuxiang , Shao, Fenli , Tan, Yang , Tan, Tao , Gu, Liyun , Zhou, Yang , Sun, Beicheng , Sun, Yang , Wu, Xuefeng and Xu, Qiang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Excessive activation of hepatic stellate cells (HSCs) is a key step in liver fibrogenesis. Here we report that CUG-binding protein 1 (CUGBP1) expression is elevated in HSCs and positively correlates with liver fibrosis severity in human liver biopsies. Transforming growth factor-beta (TGF-β) selectively increases CUGBP1 expression in cultured HSCs...
Alternative Titles
Full title
CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ac7fe1e98e6e47c8a1df5add0cbe24dc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ac7fe1e98e6e47c8a1df5add0cbe24dc
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms13498
