Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution
Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Abnormal axonal transport is associated with neuronal disease. We identified a role for DHC-1, the
C. elegans
dynein heavy chain, in maintaining neuronal cargo distribution. Surprisingly, this does not involve dynein’s role as a retrograde motor in cargo transport, hinging instead on its ability to inhibit microtubule (MT) dynamics. Neuronal...
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Full title
Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution
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TN_cdi_doaj_primary_oai_doaj_org_article_acbd2dc35519436e934590589aaef8f4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_acbd2dc35519436e934590589aaef8f4
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15063
