Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activat...
Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties
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United States: Public Library of Science (PLoS)
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English
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United States: Public Library of Science (PLoS)
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From computational simulations of a serotonin 2A receptor (5-HT(2A)R) model complexed with pharmacologically and structurally diverse ligands we identify different conformational states and dynamics adopted by the receptor bound to the full agonist 5-HT, the partial agonist LSD, and the inverse agonist Ketanserin. The results from the unbiased all-...
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Full title
Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties
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TN_cdi_doaj_primary_oai_doaj_org_article_ad94a68747b84125b3b65ad61450d023
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ad94a68747b84125b3b65ad61450d023
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ISSN
1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1002473
